Dominantly inherited cleft lip and palate in two families.
نویسندگان
چکیده
Two families with non-syndromic cleft lip and cleft palate are described. The linear pattern of inheritance through several generations is difficult to explain by conventional multifactorial models. The pedigrees strengthen the suggestion that a dominantly inherited mutation exists with a major influence on clefting of the lip and palate alone.
منابع مشابه
Cleft lip and palate, lower lip pits, and limb deficiency defects.
Cleft lip or palate and lower lip pits are typical features of the autosomal dominantly inherited Van der Woude syndrome. Limb defects have not been reported in this syndrome so far. A girl with a unilateral complete cleft lip and palate, bilateral lower lip pits, and amniotic deformities of all four limbs is reported and the possibility of chance occurrence of cleft lip and palate, lower lip p...
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ورودعنوان ژورنال:
- Journal of medical genetics
دوره 26 6 شماره
صفحات -
تاریخ انتشار 1989